Owensboro (10-2) at South Warren (12-0)

7 p.m., Spartan Stadium

Last meeting: First meeting

Radio: Talk 104.1 FM Video: Facebook.com/BGDailyNews

Notes: Friday marks the first meeting between Owensboro and South Warren. … The winner will advance to the Class 5A semifinals to play at Fern Creek or South Oldham … In eight seasons of varsity football, South Warren has reached the region final seven times. … Owensboro snapped a 14-game losing streak to Bowling Green last week with a 28-21 win at Rash Stadium. … South Warren defeated Grayson County 55-21 in the second round last week. … South Warren’s 9.3 points allowed per game ranks as the eighth-best scoring defense in the state. … Owensboro averages 37.5 points per game. … Red Devils QB Will Warren threw four TD passes against Bowling Green last week and has 3,090 passing yards for 37 TDs this season. … South Warren boasts a balanced offense with Cameron Harrison rushing for 1,184 yards and 17 TDs and Gavin Spurrier throwing for 1,977 yards and 33 TDs.

Madisonville-North Hopkins (10-2) at Franklin-Simpson (11-1)

7 p.m. James Mathews “Shadetree” Stadium

Last meeting: Franklin-Simpson won 62-6 on Nov. 10, 2017, in the second round of the playoffs

Radio: WFKN 1220-AM

Notes: Franklin-Simpson leads the all-time series 12-10, including six wins in the past seven meetings. … The Wildcats have won 21 of their last 22 games, and that includes the Class 4A state title last season. … Madisonville-North Hopkins defeated Hopkinsville last week 20-0 in the second round. … Franklin-Simpson defeated Logan County 55-19 last week. … The winner will advance to the 4A semifinals to play Moore (Louisville) or Taylor County. … The Wildcats are the top rushing team in the state with 4,312 yards at 359 rushing yards per game. … Tre Bass has 1,712 rushing yards for 28 TDs and Carlos McKinney has 1,409 yards for 18 scores. … The Maroons have won eight straight. … Jeriah Hightower leads the MNH offense with 1,707 rushing yards for 22 TDs.

Glasgow (11-1) at Walton-Verona (10-2)

6:30 p.m. CST, Walton-Verona Sports Complex

Last meeting: First meeting

Radio: WCLU 102.3-FM

Notes: Friday marks the first meeting between Glasgow and Walton-Verona. … Glasgow is back in the regional final for a second straight season. … The Scotties have outscored their first two playoff opponents 105-14. … Glasgow has either shut out or held opponents to single-digit scoring in eight games. … Walton-Verona defeated Monroe County last week 35-6. … The winner of this game will advance to the 2A semifinals to play the winner of Murray-Mayfield. … Glasgow ranks 10th in the state with 315 rushing yards per game powered by RB Nick Mitchell, who needs 52 yards to reach 2,000 for the season. … Walton-Verona has allowed 14 points in its last five contests. … Grant Grubbs leads the Bearcats defense with 112 tackles, 25.5 tackles for loss and 7½ sacks.